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🛡️ Stay ahead of pests — protect your XL companion with FRONTLINE Plus!
FRONTLINE Plus Flea and Tick Treatment for X-Large Dogs (89-132 lbs) offers a fast-acting, waterproof topical solution that kills fleas, flea eggs, larvae, chewing lice, and ticks, including those that transmit Lyme disease. Trusted for over 20 years, its unique formula with fipronil and (S)-methoprene breaks the flea life cycle and provides continuous protection for a full 30 days with a single monthly application. Safe for puppies 8 weeks and older, this treatment deposits in the skin’s sebaceous glands to maintain efficacy even after water exposure, ensuring your large dog stays pest-free and comfortable.

















| ASIN | B0002J1FP8 |
| ASIN | B0002J1FP8 |
| Active Ingredients | fipronil and (S)-methoprene |
| Age Range Description | All Life Stages |
| Allergen Information | Abalone Free |
| Best Sellers Rank | #1,018 in Pet Supplies ( See Top 100 in Pet Supplies ) #11 in Dog Flea Drops |
| Brand Name | Frontline |
| Customer Reviews | 4.4 4.4 out of 5 stars (15,248) |
| Date First Available | May 30, 2004 |
| Department | Flea & Tick |
| Dog Breed Size | Large |
| Global Trade Identification Number | 00350604287308 |
| Included Components | Package includes 3 applicators |
| Is Discontinued By Manufacturer | No |
| Item Form | Liquid |
| Item Type Name | Topical Red box |
| Item Weight | 1.6 Ounces |
| Item model number | 72220 |
| Manufacturer | Boehringer Ingelheim Animal Health |
| Manufacturer | Boehringer Ingelheim Animal Health |
| Manufacturer Part Number | 72220 |
| Manufacturer recommended age | 1 month and up |
| Model Number | 72220 |
| Product Dimensions | 5.75 x 0.75 x 4.5 inches; 1.6 ounces |
| Scent Name | Unscented |
| Target Species | Dog |
| Unit Count | 1 Count |
| Volume | 302.4 Milliliters |
| Warranty Description | If you are not satisfied with FRONTLINE Plus for any reason, please contact the Boehringer-Ingelheim Animal Health Customer Care Team at: 1-800-660-1842 |
R**S
big dog,, flee pretcion
seams to work well,
S**H
Still works in my part of the state
Easy to apply if you can make a part in your dog's hair. I always get it on my hands and wash it off as soon as I am done with the dogs. Never a problem on my skin due to this timeliness I guess. Kills the ticks who settle down to bite and still works on fleas for me. Ten miles down the road, however, it does not work anymore. Life finds away...
L**L
Works well on my dogs
Great product, works well.
L**Z
I can use this for both dogs
This works really good for my dogs and the amount that you can get I used for two dogs so it’s worth the money.
M**Y
Don’t waste your time and money on this.
Didn’t work at all! Shouldn’t have wasted the time or money on this! Ended up having to go to my vet and buying a different product! From what I’ve been told frontline has been around so long fleas are resistant to it now. Wish I could get my money back on it. Just glad that after talking to my vet and getting a different product my pets are comfortable and doing well!
D**N
Frontline covers all indoor space.
Fleas are a major problem for pets, people and indoor and outdoor environments!
A**R
Wouldn’t recommend ,
I don’t know if they change the formula or what happened but for some reason it does not work anymore. We were using this every month to treat our dogs and they still had fleas. Do not recommend this at least not for tough environments like Florida.
J**K
A must have for my dogs
I have been using Frontline for years and will continue to do so. The ease of application and the protection it provides has been favored by me and my dogs. I usually by a 3 month supply for each of my dogs. It is becomes clear if I forget to give it my dogs. In my opinion each dose does last almost exactly one month. Usually I will notice the dogs starting to scratch if I forget. As soon as I apply, by the end of the day, the scratching will stop. I love knowing my dogs are protected. I have a lot of stray cats that invade my yard and they always carry fleas so knowing my dogs get what they need to reduce the fleas is essential. To apply, I break of the top of each little vial and apply directly on the skin above their shoulders. The dogs dont even notice. It is very easy. My dogs don't like taking anything in a pill form and just spit them out, so having this where I apply topical is better for me. I highly recommend. This product works and I don't think you will be disappointed. I will add to make sure you use the right product which is determined by the weight of your pet. I don't know, nor do I want to find out if I give my 70lb dog the same product as my 120lb. Just buy the one that is designed for the weight of your dog. Other than that, I highly recommend.
Z**E
It says there is 6 doses inside but i received only 3 and package was opened!
Trustpilot
3 days ago
2 weeks ago