- FRONTLINE Plus Flea & Tick Spot Treatment for Large Breed Dogs 45-88 lbs. (Purple) Count of 3

After trying at least four different flea treatments that barely made a dent, I'm so relieved to have found these drops. They actually work - and work fast. We have two dogs who love being outside, and fleas have been an ongoing battle, especially during the warmer months. Within 24 hours of applying these drops, I noticed a huge difference. The scratching stopped, and when I checked them over, the fleas were gone. It's been several weeks now and still no sign of them coming back. Application is easy - just part the fur at the back of the neck and squeeze the tube. My dogs don't seem bothered by it at all, and it dries quickly so they can go about their day. The protection lasts the full month as advertised, which is more than I can say for some of the other brands we've tried. I've set up a subscription so I never run out because I'm not going back to the constant scratching and discomfort my pups were dealing with before. If you've been struggling to find an effective flea treatment, I highly recommend giving these a try. They've been a game-changer for us. Worth every penny for the peace of mind and happy, comfortable dogs!

This works very well on my 10 year old Golden Retriever. He is a “tick magnet” and when this medication is applied, the ticks will not embed on him. He never has a flea problem so I can’t speak to whether it works for fleas. It does not cause any skin irritation and has no odor. It seems to last the full month before ticks become a problem again.

This is hands-down the best flea and tick preventative made. I've tried others, such as Revolution, and would end up having to pick literally 20-50 attached ticks off my dog every time we went hiking and that was pretty much every day. Then they'd get in the house and be crawling on bedsheets and even across the keyboard of the computer - total nightmare. Since using Frontline, I rarely find any. Once in a while I'll find one or maybe two, but they're crawling on top of her fur and never attached. Since using Frontline, I haven't once found an attached tick on my dog nor my mom and dad's dog who is also treated with Frontline. They have had the same experience with their dog - the other brands just plain don't work - at least not for ticks, which is the main issues that we deal with, being that we live in the mountains and hike with the dogs almost ever day. Frontline works. Period. My only caveat is that you can't use this for people, which tells me that it's pretty toxic and that's why I'm giving it 4 stars instead of 5. It's pretty nasty stuff, you're supposed to avoid getting in on your skin and wash your hands immediately afterwards. If it's that toxic to humans, how safe can it be for our dogs? I really don't like the idea of putting something that's too toxic for humans on my dog and neither do my mom and dad. If we lived in the city and/or ticks weren't such an issue, we wouldn't use it. However, because of where we live and our lifestyle, the risks of tick-borne diseases outweigh the risks of the toxicity of the medicine. It's worth it for us. Decide for yourself if it's worth it for you.

Allow me to caveat this review by saying out of 700 plus reviews this is the most difficult to write as I despise having to use pesticides on our dogs. That said, we live in Tick and Flea central, surrounded by deep woods and our bulldogs are in every sense of the word family and we do whatever we must to protect them. That said if you're reading these reviews your dog or dogs are your heart too and using these products is a difficult choice to make, but it's one we have to make. On that note, it's my hope the following information has some value for you. Frontline was first put into clinical trials in 1985 shortly after the discovery of it's active ingredient Fipronil. To it's credit Frontline has maintained the safest albeit not the most effective treatment for fleas and ticks. However, the more effective products pose a significantly greater risk to your dog. It's a slippery slope, but in evaluating what's best for your dog by providing the highest level protection with the lowest risk Frontline and FrontLine Plus are in my opinion your best bet. Most tick and flea products contain Permethrin which may also be listed as Lyclear or Nix as the active ingredient. Permethrin is a lethal neurotoxin that flows through the dogs circulatory system and flushes into every major organ - including the brain where it can do dire damage. Thousands of dogs die every year from Permethrin. Although the FDA has mandated a minimal use not to exceed 750PPM companies continue to ignore the guidline because it's cheap and effective, and sadly it's our dogs that pay the price. What makes Permethrin so dangerous is that it can't distinguish between insects and mammals which of course includes human beings. It's been known to be lethal to cats since the 1970's. In fact it's so deadly to cats that even a slight transfer from dog to cat can result in seizures, brain damage and death. Permethrin is volatile as well - meaning it's airborne properties pose a threat to all who breath it in - humans included. Frontline on the other hand uses Fipronil. Fipronil is an insecticide. Like any chemical of this nature it can be lethal at too high of a dose. However studies including those from the Department of Environmental Conservation have determined time and time again that as long as the amount of Fipronil is at the correct dose for the weight and size of your dog toxicity is far easier to avoid and the product much safer for your dog. Unlike Premethrin, Fipronil is absorbed into the hair follicles and oil glands only. It is not absorbed into the dogs system nor is it volatile so you and your beloved pets and children can breath easy. The second active ingredient in FrontLine Plus is Methoprene which is a long existing and time proven IGR (insect growth regulator) it's distributed exactly like Fipronil but only acts on flea and tick eggs and Larvae - this is important because it kills these vermin at the start of a new life cycle. What is more, the diseases that ticks carry now are infinitely more serious than the dreaded Lime disease - which for decades was the only concern. Competitors to Frontline (and some Vets selling other products) claim that fleas and ticks have become resistant to Frontline - However these pests have become resistant to some degree to all pesticides and no independent research exists to confirm this claim. I can assure you I've researched this in the greatest depth. The bottom line is this - all of these products pose a risk. The wise choice is to minimize that risk in your effort to protect your best friend from the diseases these vermin carry. Again, these diseases can be infinitely more lethal than the ingredients of the protection. To that end your safest and most effective choice is Frontline or Frontline Plus. In the event your pet has a bad reaction to Frontline products these are the symptoms you would see: * Restlessness * Itching * Vomiting * Difficulty Breathing * Lethargy Should these symptoms occur, of course take your pet to your Veterinarian or emergency clinic immediately. It should be a comfort to know that unlike the toxic ingredients in most other flea and tick control products severe reactions to both Fipronil and Methoprene are rare.

Reliable flea & tick protection I’ve been using this flea and tick treatment for my dog, and it’s worked really well. It’s easy to apply, and I like that it provides long-lasting protection without needing to constantly reapply. I’ve noticed a big difference—no fleas, no ticks, and my dog hasn’t had any issues or reactions to it. It gives me peace of mind, especially during the warmer months when pests are the worst. Definitely a dependable option if you’re looking to keep your dog protected!

Buy this for our pup usually when they have a sale. Been using it for 11 years on him and no issues with either fleas or ticks here in IL & FL. Need to watch when they have it on sale, in either case it's not cheap!

The Frontline Plus flea and tick control for 45 to 88 pound dogs was worse than a disappointment. My dog is 50 pounds--well within the dosage range and become infested with fleas during the second month/dosage of usage. I'm not sure if the preventative actually worked the first month or if I just didn't notice the fleas until the fleas had multiplied enough for me to easily see them. I also don't know if I received the same quailty Frontline product through Amazon as a store/vet purchase. I have no reason to think that this was an imitation product other than some suspicions by other reviewers. Regardless, I had to use a flea dip and flea bomb my house. Once an infestation occurs, getting rid of the fleas is quite an aggravation. I'm trying Advantage II from PetSmart now to see if that will work. Hopefully, something will. June 24 2013, Advantage II didn't work either. I've had acceptable success from Certifect which I buy from my vet. I've used Certifect for over a year now. These flea and tick drops are made by Frontline but are only sold by prescription or thru a vetinarian. It works great for ticks. I've not had any problems with ticks from the first dosage. For a few days, though, after the dosage, he is a bit lethargic. However, my dog will still pick up fleas. The drops do kill the fleas but don't repel them quickly enough. Many people are having trouble with fleas because of the sucession of mild winters. The flea population isn't culled enough. During the summer months, the fleas just seem to overwhelm the medication and flea dips or additional organic sprays are necessary. I've been told that a new flea and tick pill may now be available. I know the flea pill works but I hadn't used it because I needed something for ticks. If this rumor is true, I'll definately give the pill a try. December 30, 2014. I finally found something that actually works for controlling fleas and ticks for my now 70 pound Labrador/mix. (He was a stray that my family adopted--short hair.) My vet introduced me to a new product (at the time) made by Bayer. It's a flea collar called Seresto that is sold on Amazon. I couldn't believe that a flea collar would really work. But, after having to hire Orkin to get the fleas out of my home, I was willing to try it. It's the best product that I have used for fleas and ticks. It's easy to use. I just put the collar on my dog. In few days all fleas were gone. The only ticks I ever find on my dog are the ones that he picks up during a walk or bush adventure. They are easily brushed off (when I notice them) and never attach. The collar lasts as long as advertised--8 months or in our case 5 months since he likes to swim. Unlike the drops, he is never lethargic afterwards. I have used several of these Seresto collars now and can't recommend them enough. They are sold on Amazon, by veterinarians, and I've seen them at Pet Smart as well.

Seems to work, witch is good for my dog.

It was very helpful I managed to get control of the continue scratching on her back

Very excellent and high quality

It works

My dog got extremely ill for 3 days afterwards . Seller doesn’t allow returns!