THORNE - Methyl-Guard Plus - Active Folate (5-MTHF) with Vitamins B2, B6 & B12 - Supports Methylation & Healthy Level of Homocysteine* - Gluten, Dairy & Soy-Free - 30 Servings

High quality B complex! Helpful for MTHFR gene mutation. I have been using them for about six months now and notice a huge difference in my cycle regularity, as it has very high amounts of B6 and a methylated form, I’m convinced is due to this product. My menstrual cramps have all but almost completely disappeared, which is absolutely amazing considering I have struggled with that since my teens could not recommend this more, especially for women struggling with similar issues.

Love! It’s high quality, easy to take, and has really helped lower my homocysteine levels as recommended by my doctor. I appreciate that it uses active forms of B vitamins like 5-MTHF for better absorption. Thorne is such a trusted, clean brand, which gives me extra confidence in what I’m taking. I feel more balanced and energized since adding it to my routine—definitely a product I’ll keep using!

Great vitamins that give good energy

I starting taking this after getting some (SpectraCell) testing done that said I was deficient in the various B vitamins and I had the MTHFR genetic defect that prevents methylation. I felt like crap for the last decade and my usual doctors weren't of any help. I eat very healthy and eat very well too as I thought that would make me better. I won't go into details but I always knew something was wrong and nothing else worked. Anyway, so i read about methyl folate and methylation, MTHFR etc. and I get this to start to "fix"it. Immediately I felt FAR worse than I ever did before. Headaches, brain fog, extreme fatigue. So I stopped taking it and I go back to the sites and learn this is normal reaction. So then I read you should boost your other B vitamins first without the methyl folate or b12 and then add this back in. So I did with a product called B Minus for about 2 months then I added this product back in. Now 2 months in to taking this I feel like I'm finally waking up and getting more energy and I feel fantastic. No side effects. And a lot of my old symptoms are gone or fading away. I held off writing a review b/c I've been so disappointed after taking so many supplements over the years but this one seems to be actually working. It can take 6 -12 months to see full results and get your levels back to where they should be so I can't imagine how I'll feel by then. I'm going to retest through Spectracell in 6 months and see where my levels are at. If you're not familiar with Spectracell, look into it. Most regular doctors won't have it and it's not covered under insurance. I actually went to a nutritionist to get it done. It's the best decision I've ever made for my health. I'm just sad that it took me so long to find the answers. Good luck to you.

I am 62 and take 2 vitamins a day per my Dr's instructions. She found that i have the MTHFR deficiency doing a swab test in her office. My body responded really quickly to the vitamin. It has helped me get a lot of water off of my body that i didn't know i was holding. So far 20 pounds of water and that's a lot! I did go through a very short few days where i didn't feel very well but i had read the reviews and instructions and kept taking the vitamins and it past. On the other side of that the energy started to build up. My brain is still 30 but my body isn't 80 any more it's coming down to be of age with energy and ability to accomplish things in a day. I also have a B12 deficiency so i have to take extra B12 because there isn't enough in the vitamin for me but i think because of it I think I'm absorbing it better. I just started my 2nd bottle and have more energy than I've had in 20 years. I never want to run out of this! Highly recommend.

I’ve been taking this for almost a yr or maybe 9 mos per my Dr. it has been confusing at times as I fill a weekly box with my supplimants for each day as I take quite a few. I’ve noticed that the capsules turn really dark after being in the box. At first I was sure it was turmeric as I had filled capsules with turmeric and I’m afraid I may have thrown some away which this are way to pricy to throw away. I’ve just recently realized they are changing colors as I knew absolutely I did not put the wrong thing in. I wish the manufacturer would address this as to wheather it affects the potency. Surely it doesn’t. Either way just a heads up that they will change from light to a dark burnt Orange. As long as mine are in the original bottle they stay same. Otherwise I have no complaints.

I'm a big believer in investing in high-quality supplements, and Thorne Research is one of the brands I trust most. Their Methyl-Guard Plus is a great option for anyone looking to support their methylation pathways, especially if they have the MTHFR gene mutation. I've been using Methyl-Guard Plus for a few months now, and I've noticed a significant improvement in my energy levels and overall well-being. I also appreciate that it doesn't cause any stomach upset, which is a common problem with other B-vitamin supplements. If you're looking for a high-quality, effective B-vitamin supplement, I highly recommend Thorne Research's Methyl-Guard Plus.

Great product, contains Betaine?TMG too which is essential for proper maintenance of homocysteine levels.

Recently I found out I’m anemic and distant to go on medication so I did my research and found this to have all the things I need.

Only 5 days of taking it but I feel like it’s doing me good

good product

Good to take supplements, still cannot see the justification of this high price!